The Sewees were a Native American nation based along the Santee River and the Sea Islands of South Carolina. 

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Sewees | South Carolina Public Radio
Sewees | South Carolina Public Radio

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“S” is for Sewees. The Sewees were a Native American nation based along the Santee River and the Sea Islands. In 1670 it was the Sewees who showed the English colonists the best harbors. They helped...